AssayGate Testing Service References

Although most of our clients from pharmaceutical companies do not present our assay results in public domains, many academic customers have published their data generated by AssayGate in various peer-reviewed journals and scientific reports:

Zhang, R et al., Macrophage-Targeted Sodium Chlorite (NP001) Slows Progression of Amyotrophic Lateral Sclerosis (ALS) through Regulation of Microbial Translocation, Biomedicines 2022, 10(11), 2907; https://doi.org/10.3390/biomedicines10112907 (2022)

Sims, JT et al., Insights into adult atopic dermatitis heterogeneity derived from circulating biomarker profiling in patients with moderate-to-severe disease, Experimental Dermatology. 2021;30:1650–1661 (2021).

Powles, T et al., Outcomes based on plasma biomarkers in METEOR, a randomized phase 3 trial of cabozantinib vs everolimus in advanced renal cell carcinoma, BMC Cancer (2021) 21:904, https://doi.org/10.1186/s12885-021-08630-w (2021)

Ciszewski, C et al., Identification of a γc Receptor Antagonist That Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21, Gastroenterology,158:625–637 (2020).

Ljubenkov, PA et al., Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency, Front. Neurol., doi: https://doi.org/10.3389/fneur.2019.01004 (2019)

Rimassa, L et al., Outcomes based on plasma biomarkers for the phase III CELESTIAL trial of cabozantinib (C) versus placebo (P) in advanced hepatocellular carcinoma (aHCC), Annals of Oncology, https://doi.org/10.1093/annonc/mdz247.006 (2019).

Carota, G et al., Antiproliferative Effects of Ellagic Acid on DU145 Cells, The Open Biochemistry Journal, doi: 10.2174/1874091X01913010023, 13, 23-31(2019).

Lakhani, HV et al., Beneficial Role of HO-1-SIRT1 Axis in Attenuating Angiotensin II-Induced Adipocyte Dysfunction, Int. J. Mol. Sci. 2019, 20, 3205; doi:10.3390/ijms20133205 (2019).

Bajaj, BS et al., Periodontal Therapy Favorably Modulates the Oral-Gut-Hepatic Axis in Cirrhosis, Am J Physiol Gastrointest Liver Physiol. doi: 10.1152/ajpgi.00230 (2018).

Loftis, JM et al., S100B and Inflammatory Cytokine Levels in Blood as Potential Markers of Blood–Brain Barrier Damage and Psychiatric Impairment in Comorbid Hepatitis C Viral Infection and Alcohol Use Disorder, Alcohol Clin Exp Res, Vol 42, No 8, 1466–1475 (2018).

Crowgey, EL et al., A Systems Biology Approach for Studying Heterotopic Ossification: Proteomic Analysis of Clinical Serum and Tissue Samples, Genomics Proteomics Bioinformatics 16, 212–220 (2018).

Arjomandi, M et al., Respiratory Responses to Ozone Exposure. MOSES (The Multicenter Ozone Study in Older Subjects), DOI: 10.1164/rccm.201708-1613OC (2017). Am J Respir Crit Care Med Vol 197, Iss 10, pp 1319–1327(2018).

Lee, BC et al, Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo, Nature, Sci Rep 7:5119, doi:10.1038/s41598-017-05230-2 (2017).

Heck, BE et al., Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same, United States Patent Application 20170283385 (2017).

Bhatwadekar, AD et al., Conditional Deletion of Bmal1 Accentuates Microvascular and Macrovascular Injury, The American Journal of Pathology, Vol. 187, No. 6 (2017).

Zhao, M et al., Discovery of a Prefusion RSV F-Specific Monoclonal Antibody that Provides Greater in vivo Protection than the Murine Precursor of Palivizumab Running title: Prefusion RSV-F-specific passive antibody immunity, J. Virol. doi:10.1128/JVI.00176-17 (2017).

Powles, T et al., Outcomes based on plasma biomarkers in METEOR, a randomized phase 3 trial of cabozantinib (C) vs everolimus (E) in advanced renal cell carcinoma (RCC), ESMO 2017 Congress, Annals of Oncology 28 (suppl_5): v295-v329. 10.1093/annonc/mdx371 (2017).

Leibowitz‑Amit, R et al., Changes in plasma biomarkers following treatment with cabozantinib in metastatic castration‑resistant prostate cancer: a post hoc analysis of an extension cohort of a phase II trial, J Transl Med, 14:12 DOI 10.1186/s12967-015-0747-y (2016).

Su, Z et al., Acupuncture plus low-frequency electrical stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy, J Appl Physiol 120: 426–436 (2016).

Kang, DJ et al., Rifaximin Exerts Beneficial Effects Independent of its Ability to Alter Microbiota Composition, Clinical and Translational Gastroenterology (2016) 7, e187; doi:10.1038/ctg.2016.44 (2016).

Morabito, KM et al., Intranasal administration of RSV antigen-expressing MCMV elicits robust tissue-resident effector and effector memory CD8 þ T cells in the lung, Mucosal Immunology, DOI:10.1038/mi.2016.48 (2016).

Zhu, AX et al., Biomarker Analyses of Clinical Outcomes in Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib with or without Erlotinib in the SEARCH Trial, Clinical Cancer Research, DOI: 10.1158/1078-0432.CCR-15-2883 (2016).

Schwarz, B et al., Virus-Like Particles Encapsidating Respiratory Syncytial Virus M and M2 Proteins induce robust T cell responses, ACS Biomater. Sci. Eng., DOI: 10.1021/acsbiomaterials.6b00532 (2016)

Chen, Q et al., Higher Diet Quality and Decreased Inflammation in Young Women, The FASEB Journal vol. 30 no. 1 Supplement 902.12 (2016)

Dominguez, JM et al., Combination Therapies Prevent the Neuropathic, Proinflammatory Characteristics of Bone Marrow in Streptozotocin-Induced Diabetic Rats, Diabetes,64:643–653 | DOI: 10.2337/db14-0433 (2015)

Bajaj JS et al., Salivary Microbiota Reflects Changes in GutMicrobiota in Cirrhosis With Hepatic Encephalopathy, Hepatology, 62(4). DOI: 10.1002/hep.27819 (2015)

Priest CA et al., Preclinical safety of human embryonic stem cell-derived oligodendrocyte progenitors supporting clinical trials in spinal cord injury, Regenerative Medicine, DOI:10.2217/rme.15.57 (2015)

Miller RG et al., Randomized phase 2 trial of NP001–a novel immune regulator: Safety and early efficacy in ALS, Neurol Neuroimmunol Neuroinflamm, 2(3): e100 (2015), DOI: 10.1212/NXI.0000000000000100 (2015)

Tabernero J et al., Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial, The Lancet Oncology, 16(8), 937–948 (2015), DOI: http://dx.doi.org/10.1016/S1470-2045(15)00138-2 (2015)

Nobles, C et al., Correlation of Urine and Plasma Cytokine Levels Among Reproductive-Aged Women, Eur J Clin Invest.,45(5):460-5. doi: 10.1111/eci.12428 (2015).

Beli, et al., Regulation of the diurnal circulation of monocytes in type 1 diabetic mice: implications for diabetic retinopathy (DR), Investigative Ophthalmology & Visual Science Vol. 56, 1751 (2015).

Bajaj, JS er al., Randomized clinical trial: lactobacillus gg modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis, Aliment Pharmacol Ther. 39(10): 1113–1125. doi:10.1111/apt.12695 (2014).

Ahluwalia V et al., Correction of Hyponatremia Improves Cognition, Quality of Life, and Brain Edema in Cirrhosis, Journal of Hepatology, DOI: http://dx.doi: 10.1016/j.jhep.2014.07.033 (2014).

Pesce P et al., Characterization of a murine model of cardiorenal syndrome type 1 by high-resolution Doppler sonography, Journal of Ultrasound, DOI: 10.1007/s40477-014-0129-y (2014).

Volk A et al., Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML, JEM, 211:6, 1093-1108, doi: 10.1084/jem.20130990 (2014).

Szema AM et al., Iraq Dust Is Respirable, Sharp, and Metal-Laden and InducesLung Inflammation With Fibrosis in Mice via IL-2 Upregulationand Depletion of Regulatory T Cells, JOEM, 56:3, 243-251 (2014).

Sodhi K et al., PPARδ binding to heme oxygenase 1 promoter prevents angiotensin II-induced adipocyte dysfunction in Goldblatt hypertensive rats, International Journal of Obesity, 38, 456–465 (2014).

Hazra S et al., Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model, Diabetologia, Volume 56, Issue 3, pp 644-653 (2013).

Kakiyama G et al., Colonic Inflammation and Secondary Bile Acids in Alcoholic Cirrhosis, American Journal of Physiology - Gastrointestinal and Liver Physiology, DOI: 10.1152/ajpgi.00315.2013 (2013).

Angevine K et al., Loss of menin mediated by endothelial cells treated with CoPP is associated with increased maturation of adipocytes, Adipocyte 2:4, 207–216 (2013).

Roix J et al., TNF-α blockade is ineffective in animal models of established polycystic kidney disease, BMC Nephrology, 14:233 doi:10.1186/1471-2369-14-233 (2013).

Vanella L et al., Apoptotic markers in a prostate cancer cell line: Effect of ellagic acid, Oncology Reports, doi: 10.3892/or.2013.2757 (2013).

Garcia AE et al., Erosive Arthritis and Hepatic Granuloma Formation Induced by Peptidoglycan Polysaccharide in Rats Is Aggravated by Prasugrel Treatment, PLoS ONE 8(7): e69093. doi:10.1371/journal.pone.0069093 (2013).

Vanella L et al., Effects of Ellagic Acid on Angiogenic Factors in Prostate Cancer Cells, Cancers 2013, 5, 726-738; doi:10.3390/cancers5020726 (2013).

Monu SR et al., HO-1 Induction Improves The Type-1 Cardiorenal Syndrome in Mice With Impaired Angiotensin II–Induced Lymphocyte Activation, Hypertension, doi: 10.1161/​HYPERTENSIONAHA.111.00495 (2013).

Kim DH et al., Cyclooxygenase-2 Dependent Metabolism of 20-HETE Increases Adiposity and Adipocyte Enlargement in Mesenchymal Stem Cell Derived Adipocytes, J. Lipid Res. doi:10.1194/jlr.M033894 (2013).

Dayyani F et al., Increased serum insulin-like growth factor-1 levels are associated with prolonged response to dasatinib-based regimens in metastatic prostate cancer, The Prostate, doi: 10.1002/pros.22645 (2013).

Bethunaickan R et al., Anti–tumor necrosis factor α treatment of interferon-α–induced murine lupus nephritis reduces the renal macrophage response but does not alter glomerular immune complex formation, ARTHRITIS & RHEUMATISM Vol. 64, No. 10, 3399–3408. DOI 10.1002/art.34553 (2012).

Eisen T et al., Regorafenib for patients with previously untreated metastatic or unresectable renal-cell carcinoma: a single-group phase 2 trial, Lancet Oncol, 13: 1055–62 (2012).

Jarajapu YP et al., Activation of the ACE2/Angiotensin-(1–7)/Mas Receptor Axis Enhances the Reparative Function of Dysfunctional Diabetic Endothelial Progenitors, Diabetes, doi: 10.2337/db12-0808 (2012).

Lee LS et al., Differentiating Branch Duct and Mixed IPMN in Endoscopically Collected Pancreatic Cyst Fluid via Cytokine Analysis, Gastroenterology Research and Practice, doi:10.1155/2012/247309 (2012).

Edsberg LE et al., Analysis of the proteomic profile of chronic pressure ulcers, Wound Repair and Regeneration, 20(3), 378–401(2012).

Kou JH et al., Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease, Journal of Neuroimmunology, 244(1-2), 70-83 (2012).

Conklin DJ et al., Effects of Subchronic Diesel Engine Emissions Exposure on Plasma Markers in Rodents: Report on 1- and 3-Month Exposures in the ACES Bioassay, Health Effects Institute Research Report 166, 189-223 (2012).

Bajaj JS et al., The Colonic Mucosal Microbiome Differs from Stool Microbiome in Cirrhosis and Hepatic Encephalopathy and is Linked to Cognition and Inflammation, Am J Physiol Gastrointest Liver Physiol, doi: 10.​1152/​ajpgi.​ 00152.2012 (2012).

Popmihajlov Z et al., Conditional IL-2 Gene Deletion: Consequences for T Cell 189-223 Proliferation, Front Immunol., 3:102. doi: 10.3389/fimmu.2012.00102 (2012).

Burgess AP et al., Heme oxygenase (HO-1) rescue of adipocyte dysfunction in HO-2 deficient mice via recruitment of epoxyeicosatrienoic acids (EETs) and adiponectin, Cell Physiol Biochem., 29(1-2):99-110 (2012).

Tietjen GE et al., Adverse Childhood Experiences Are Associated With Migraine and Vascular Biomarkers, Headache, doi: 10.1111/j.1526-4610.2012.02165.x (2012).

Bajaj JS et al., A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy, Metabolic Brain Disease, doi:10.1007/s11011-012-9303-0 (2012).

Saha A et al., The blood-brain barrier is disrupted in a mouse model of infantile neuronal ceroid lipofuscinosis: amelioration by resveratrol, Hum. Mol. Genet., doi: 10.1093/hmg/dds038 (2012).

Kaseb AO et al., Efficacy of Bevacizumab plus Erlotinib for Advanced Hepatocellular Carcinoma and Predictors of Outcome: Final Results of a Phase II Trial, Oncology, 82:67-74. doi: 10.1159/000335963 (2012).

Yadav V et al., Recombinant T-Cell Receptor Ligand (RTL) for Treatment of Multiple Sclerosis: A Double-Blind, Placebo-Controlled, Phase 1, Dose-Escalation Study, Autoimmune Diseases, doi:10.1155/2012/954739 (2012).

Vanella L et al., Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes, Prostaglandins Other Lipid Mediat. 2011 November ; 96(0): 54–62. doi:10.1016/j.prostaglandins (2011).

Bajaj JS et al., Linkage of Gut Microbiome with Cognition in Hepatic Encephalopathy, Am J Physiol Gastrointest Liver Physiol ajpgi.0019; doi: 10.1152/ajpgi.00190 (2011).

Kumarasamy S et al., Dysglycemia induces abnormal circadian blood pressure variability, Cardiovascular Diabetology, 10:104 doi:10.1186/1475-2840-10-104 (2011).

Conklin DJ et al., Acrolein-induced dyslipidemia and acute-phase response are independent of HMG-CoA reductase, Molecular Nutrition & Food Research, doi: 10.1002/mnfr.201100225 (2011).

Sarkar DK et al., Transplantation of β-endorphin neurons into the hypothalamus promotes immune function and restricts the growth and metastasis of mammary carcinoma, Cancer Research, doi: 10.1158/0008-5472.CAN-11-1610 (2011).

Wilhelm CJ et al., Corticotropin releasing factor-1 receptor antagonism alters the biochemical, but not behavioral effects of repeated interleukin-1β administration, Neuropharmacology, doi:10.1016/j.neuropharm.2011.07.040 (2011).

Liu Z et al., IFN-α Confers Resistance of Systemic Lupus Erythematosus Nephritis to Therapy in NZB/W F1 Mice, The Journal of Immunology, doi: 10.4049/jimmunol.1004142 (2011).

Paulo JA et al., Cytokine profiling of pancreatic fluid using the ePFT collection method in tandem with a multiplexed microarray assay, Journal of Immunological Methods, doi:10.1016/j.jim.2011.04.012 (2011).

Warner-Schmidt JL et al., Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans, PNAS, doi: 10.1073/pnas.1104836108 (2011).

Xin DL et al., Aging enhances serum cytokine response but not task-induced grip strength declines in a rat model of work-related musculoskeletal disorders, BMC Musculoskeletal Disorders, 12:63 (1-11). doi:10.1186/1471-2474-12-63 (2011).

Bajaj JS et al., Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy, Gastroenterology, 140(2), 478-487 (2011).

Liu Z et al., Interferon-α accelerates murine systemic lupus erythematosus in a T cell-dependent manner. Arthritis Rheum., 63(1):219-229. doi: 10.1002/art.30087 (2011).

Darnall BD et al., Pilot study of inflammatory responses following a negative imaginal focus in persons with chronic pain: analysis by sex/gender. Gender Medicine, 7(3):247-260. doi:10.1016/j.genm.2010.06.003 (2010).

Loftis JM et al., Methamphetamine causes persistent immune dysregulation: a cross-species, translational report, Neurotoxicity Research, doi:10.1007/s12640-010-9223-x (2010).

Brown CM et al., Production of proinflammatory cytokines and chemokines during neuroinflammation: Novel roles for estrogen receptors α and β, Neuroendocrinlogy 151(10), doi:10.1210/en.2010-0371 (2010).

Nikodemova M et al., Minocycline attenuates experimental autoimmune encephalomyelitis in rats by reducing T cell infiltration into the spinal cord, Journal of Neuroimmunology 219, 33-37 (2010).

Kalia V et al., Prolonged interleukin-2Rα expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo, Immunity 32, 91-103 (2010).

Mallampati, R. et al., Evaluation of EpiDerm full thickness-300 (EFT-300) as an in vitro model for skin irritation: Studies on aliphatic hydrocarbons, Toxicol In Vitro., 24(2): 669–676 (2010); doi: 10.1016/j.tiv.2009.08.019 (2009).

Winer S et al., Normalization of obesity-associated insulin resistance through immunotherapy, Nature Medicine 15(8), 921-929 (2009). Badman MK et al., A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss, Am J Physiol Endocrinol Metab 297: E1197-E1204 (2009).

Wu S et al., Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF-kB signaling, Cardiovascular Research doi:10.1093/cvr/cvp180 (2009).

Petty AP et al., Targeting migration inducting gene-7 inhibits carcinoma cell invasion, early primary tumor growth, and stimulates monocyte oncolytic activity, Mol Cancer Ther 8(8), 2412-2423 (2009).

Jin JJ et al., Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease, Journal of Neuroinflammation 5:23, doi:10.1186/1742-2094-5-23 (2008).

Saha A et al., RAGE signaling contributes to neuroinflammation in infantile neuronal ceroid lipofuscinosis, FEBS Letters 582, 3823-3831 (2008).

Johnson TE et al., Chemopreventive effect of kava on 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene–induced lung tumorigenesis in A/J mice, Cancer Prev Res 1(6), 430-438 (2008).